Mood & anxiety
Everything on depression, anxiety, panic and obsessive-compulsive symptoms: how they work, which treatments have the best evidence, the new ones worth knowing about, and tools to measure where you are. The suicide-prevention guides live here too, quietly, at /safety.
16 posts, 1 tool and 5 screeners, last updated Oct 2, 2026. Short link: doctorreid.com/mood
If you or someone you love is struggling right now, call or text 988 (US, any hour), or text HOME to 741741. If someone is in danger, call 911 or go to the nearest emergency room. Outside the US, see findahelpline.com.
- The reuptake eraHow blocking the pumps that clear serotonin, noradrenaline and dopamine built modern psychiatry, from Prozac to centanafadine, the first triple reuptake inhibitor.Oct 2, 2026
- One size fits fewPrecision psychiatry: where it stands, how far it has come and where it goes next, with a plain-language guide to pharmacogenomic (PGx) test reports.Oct 1, 2026
- The doubting diseaseWhat OCD is, where it comes from, how it's measured, why it travels with anorexia, and how exposure therapy works, with a guided practice you can try.Oct 1, 2026
- The worry engineGeneralized anxiety disorder up close, the rest of the DSM anxiety family, a validated self-check for each, an interactive anxiety map, and the MM120 (LSD) trials.Oct 1, 2026
- The warning in the boxWhy some psychiatric medicines carry a suicide warning, which ones do and don't, what twenty years of science shows, and how to stay safe when treatment starts.Sep 29, 2026
- What lies underneathHow science understands suicidal pain: the leading theories, from Joiner's interpersonal theory to the three-step model, and the neurobiology underneath.Sep 26, 2026
- A plan for the hardest hourSafety planning: what the evidence says, how to make a plan, and a free tool to build yours, save it as a PDF or text it to someone you trust.Sep 26, 2026
- Not evenly sharedWho suicide touches most, by age, place, condition and community; why LGBTQ+ people carry higher risk; and what protects.Sep 26, 2026
- Keeping people safeWhat prevents suicide, how to check in on someone, the honest science on SSRIs, and what each of us can do.Sep 21, 2026
- Ketamine and the suicidal crisisWhat we know and what we don't, plus a white paper (PDF) that separates rapid relief of suicidal thinking from the unanswered question of prevention.Sep 21, 2026
- How therapy worksYour brain doesn't perceive the world; it predicts it. An evidence-graded guide to the predictive brain and why talking with someone changes it.Aug 27, 2026
- Serotonin & serotonin syndromeWhat serotonin is, what serotonin syndrome actually is, how to recognize it (Hunter criteria), which drug combinations matter, and what to do.Aug 18, 2026
- 4-OH-DiPT: a research reportThe shortest-acting oral psychedelic Shulgin ever described, now a prodrug in three Phase 2 trials.Aug 4, 2026
- 5-MeO-DMT: a research reportThe largest reported effect size in the field, from the shortest session, and an indigenous tradition that appears to have been invented in 1984.Aug 4, 2026
- LSD: a research reportA circulatory stimulant that failed, became a counterculture, and is now in Phase 3 for generalized anxiety.Aug 4, 2026
- Psilocybin and psilocin: a research reportTwo completed Phase 3 trials, an NDA in preparation, and an effect size worth arguing about.Aug 4, 2026
- PHQ-9The standard nine-question depression check.Screener
- MADRS-SA self-rated depression severity scale.Screener
- Feeling lowEvery depression-related instrument in the lab.Screener
- Anxiety checksGAD-7 and related anxiety scales, scored and explained.Screener
- OCD checksObsessive-compulsive symptom scales.Screener
- Suicide preventionWhat prevents suicide, what lies underneath, and a safety-plan builder. For people who are struggling and the people who love them.Tool
Numbers worth saving
- 988 Suicide & Crisis LifelineCall or text 988, or chat at 988lifeline.org. Any hour, in the US. Veterans press 1; Spanish press 2.
- Crisis Text LineText HOME to 741741, any hour.
- The Trevor ProjectFor LGBTQ+ young people: 1-866-488-7386, or text START to 678-678.
- SafeUTA free Utah app with licensed crisis counselors by chat or call, any hour.
- Outside the USfindahelpline.com lists free lines in more than 130 countries.
Related topics
Psychopharmacology, ADHD & attention, Mind & perception, Food & eating, Therapy, Psychedelic medicine, Suicide prevention
Other topics
Suicide prevention, Psychedelic medicine, Therapy, Mind & perception, Psychopharmacology, ADHD & attention, PTSD & trauma, Body & health, Food & eating. Or see all posts, newest first.